THE 2-MINUTE RULE FOR SBS88

In vitro experiments of human most cancers cell lines have indicated that SBS2/SBS13 mutagenesis is episodic, transpiring in bursts with prolonged durations of intervening silence31. To research regardless of whether APOBEC mutagenesis in usual modest intestine cells in vivo is episodic, we examined crypt phylogenetic trees and located that APOBEC-